PI: Kari North, Ph.D., University of North Carolina, Chapel Hill



CALiCo Consortium:

Genetic Epidemiology of Causal Variants Across the Life Course Phase II (CALiCo II) is a consortium of population based studies that have entered a partnership to provide optimal opportunities to investigate the association of genetic variants associated with complex diseases in ancestrally diverse populations. The first phase of CALiCo, CALiCo I, assessed the importance of common variants in diverse U.S. populations, public health-relevant contexts, and epochs in the natural history of chronic disease. CALiCo II will expand on these studies to assess low frequency [1-5% minor allele frequency (MAF)] and rare (0.1-1% MAF) coding and/or potentially functional genomic variants. The consortium comprises the Atherosclerosis Risk in Communities (ARIC) Study, the Coronary Artery Risk Development in Young Adults (CARDIA) Study, the Hispanic Community Health Study (HCHS/SOL), the Strong Heart Study (SHS) and the Strong Heart Family Study (SHFS); and a Central Genotyping Core Laboratory located at the Human Genetics Center, University of Texas Health Sciences Center at Houston.

These population-based studies have considerable breadth of phenotype characterization and population sizes to permit informative assessments of a wide range of variants, traits and public health contexts, with power sufficient to identify associations and interactions. This consortium brings several of the most informative studies extant and its core genotyping laboratory to a collaboration with other studies funded by this RFA, contributing well characterized cohorts under long term follow up, which include three main ethnic and racial groups in the U.S. (African Americans, Hispanics/Latinos, American Indians), and the ability to extend the characterization of genes and their associated traits and illnesses across the life course. In collaboration with Population Architecture Using Genomics in Epidemiology (PAGE) studies, CALiCo II will explore the associations of genetic variation with a broad range of phenotypes, including conditions that disproportionately burdens U.S. ethnic and racial minorities.